That’s a great question. It depends on what do you mean by challenging.
For example, I believe that one of the most challenging viruses was Smallpox. It killed over 300 million people and the epidemics were pretty awful devastating countries. Fortunately, after loads of efforts and thanks to a wonderful vaccine, smallpox was erradicated already over 50 years ago!
Another really challenging virus is Ebola. Ebola Virus has a very high mortality (9 out of 10 people infected may die within just a few weeks). Currently, there is an ongoing outbreak of Ebola in Congo! Hopefully, it will be controlled soon!
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